Description

Loblase (Labetalol Hydrochloride Injection IP 5 mg) – The Trusted Choice in Hypertensive Emergencies

By Monark Criticare – Elevating Critical Care with Precision and Trust

Loblase, a premium product from Monark Criticare, is a Labetalol Hydrochloride IP 5 mg Injection available in a 2*4ml AMP TRAY PACK. It is specially formulated to manage acute hypertensive conditions in clinical settings. With its dual mechanism of action and rapid efficacy, Loblase stands out as a preferred beta-blocker injection among healthcare professionals who demand swift and stable blood pressure control in critically ill patients.

Monark Criticare is dedicated to providing high-quality, reliable critical care formulations. Loblase is manufactured in accordance with stringent pharmaceutical standards, ensuring sterility, potency, and patient safety in every ampoule.

Composition and Packaging

• Active Ingredient: Labetalol Hydrochloride IP

• Strength: 5 mg per ml

• Dosage Form: Injectable Solution

• Pack Size: 2 ampoules of 4 ml each (2*4 ml)

• Packaging Type: AMP Tray Pack for enhanced protection and easy handling

Pharmacological Classification

Labetalol belongs to the class of combined alpha- and beta-adrenergic receptor blockers. It is widely used in emergency medicine and critical care to manage hypertensive crises and severe hypertension during surgery or pregnancy-related complications such as pre-eclampsia or eclampsia.

 How it works?

Lobetatol Hydrochloride (Loblase) exerts its effects via:

• Beta-adrenergic blockade (non-selective): It blocks both β1 and β2 receptors, leading to a reduction in heart rate, cardiac output, and renin release.

• Alpha-1 blockade: Causes vasodilation, decreasing peripheral vascular resistance without significantly reducing cardiac output.

This dual mechanism helps reduce blood pressure without causing reflex tachycardia, a common issue with pure vasodilators.

Indications and Clinical Uses

Loblase is indicated for:

• Hypertensive Emergencies – A condition requiring immediate BP lowering to prevent target organ damage.

• Severe Hypertension during Pregnancy – Particularly effective in pre-eclampsia or eclampsia.

• Postoperative Hypertension – Used in patients recovering from surgery with elevated blood pressure.

• Controlled Hypotension during Surgery – Assists in maintaining stable intraoperative conditions.

• Pheochromocytoma Crisis – As part of an alpha and beta blockade approach.

• Acute Aortic Dissection – Rapid BP reduction is crucial, and Labetalol is often the first-line agent.

Dosage and Administration

Route of Administration: Intravenous (IV) injection or infusion.
Initial Dose: Typically, 20 mg IV over 2 minutes.
Titration: Additional doses of 40-80 mg may be administered every 10 minutes until desired BP is achieved (maximum cumulative dose: 300 mg).
Infusion Option: Continuous IV infusion at 1-2 mg/min.

Administration must always be under strict monitoring in a hospital or ICU setup, with attention to heart rate, blood pressure, and ECG.

Benefits of Loblase by Monark Criticare

1. Rapid Onset of Action – Begins lowering BP within 5 minutes of IV administration.

2. Short Duration – Effects wear off in 2–4 hours, making it ideal for acute control.

3. Stable Hemodynamics – Reduces BP without causing excessive hypotension or tachycardia.

4. Dual Action – Alpha and beta blockade provide a unique advantage in hypertensive emergencies.

5. Safe in Pregnancy – Preferred drug for severe hypertension in pregnant patients.

6. Convenient Packaging – Tray pack ensures sterility, ease of storage, and administration.

7. Trusted Manufacturing – Produced under GMP-certified facilities with rigorous quality checks.

Side Effects and Precautions

Like all medications, Loblase may cause some side effects, especially if not administered properly or in overdosage:

Common Side Effects:

• Dizziness or lightheadedness

• Fatigue

• Nausea

• Scalp tingling

• Nasal congestion

Serious Adverse Effects:

• Bradycardia (slow heart rate)

• Heart block

• Hypotension

• Bronchospasm (especially in asthmatic patients)

• Liver function disturbances (rare)

Precautions:

• Not recommended in patients with asthma or COPD due to risk of bronchospasm.

• Use with caution in heart failure or bradycardia.

• Monitor renal and hepatic functions during prolonged usage.

• Avoid abrupt discontinuation after long-term therapy to prevent rebound hypertension.

• Continuous ECG and BP monitoring is advised during administration.

Drug Interactions

Lobetalol may interact with:

• Calcium Channel Blockers (e.g., Verapamil) – Risk of AV block or hypotension.

• General Anesthetics – Can enhance myocardial depression.

• Insulin and Antidiabetics – May mask symptoms of hypoglycemia.

• Other Antihypertensives – Additive hypotensive effect.

Always inform the treating physician about all concurrent medications.

Why Choose Loblase from Monark Criticare?

Monark Criticare is a rising star in India’s critical care pharmaceutical segment, known for its commitment to quality, affordability, and innovation. Each product is crafted after extensive research and quality validation.

Loblase meets the demanding needs of ICUs, emergency rooms, and critical care physicians by offering a formulation that is:

• Clinically reliable

• Pharmacologically effective

• Manufactured with precision

• Available in well-packaged ampoules for sterile use

• Competitively priced for public and private healthcare institutions

Storage and Handling

• Store at controlled room temperature between 15°C to 30°C.

• Protect from light and freezing.

• Discard unused portion after opening the ampoule.

• Keep out of reach of children.

Conclusion

Loblase (Labetalol Hydrochloride Injection IP 5 mg) is a fast-acting, dependable solution for acute hypertensive states. Backed by Monark Criticare’s assurance of quality, it has become a vital component of emergency medicine and critical care settings across hospitals.

Whether it’s managing life-threatening hypertension in the ICU, ensuring safe maternal outcomes in obstetric emergencies, or maintaining hemodynamic stability during surgeries, Loblase is the clinician’s go-to beta-blocker.

Choose Loblase. Choose confidence in critical care.